House of M
2005When the Avengers and X-Men debate what to do about an increasingly unstable Scarlet Witch, Wanda Maximoff reshapes reality into a world where mutants are the dominant species and Magneto rules as sovereign. As the heroes slowly remember the real world, Wanda is confronted and utters the three words that change the Marvel Universe forever: "No more mutants." Decimation reduces the global mutant population from millions to 198.
8 core issues, 0 optional tie-ins/crossovers

Reality is rewritten — mutants rule, Magneto is king, and no one remembers the world before

The new reality explored; Wolverine is an agent of S.H.I.E.L.D. and remembers everything

Wolverine begins assembling heroes who remember the real world; Layla Miller awakens others

The resistance grows; heroes confront the truth about who created this reality

The heroes march on Magneto's stronghold in Genosha

Battle in Genosha; the truth about Quicksilver's role is revealed

Magneto turns on Quicksilver; Wanda witnesses her father's rage

'No more mutants' — Wanda depowers 98% of mutantkind; reality snaps back; Decimation begins